![]() RESEARCH DESIGN AND METHODS-We performed cross-sectional analyses of A1C across age categories in 2,473 nondiabetic participants of the Framingham Offspring Study (FOS) and in 3,270 nondiabetic participants from the National Health and Nutrition Examination Survey (NHANES) 2001–2004. We examined whether A1C was associated with age in nondiabetic subjects and in subjects with normal glucose tolerance (NGT) in two population-based cohorts. This underscores the importance of personalized treatment plans and regular monitoring to maintain optimal metabolic health.OBJECTIVE-Although glycemic levels are known to rise with normal aging, the nondiabetic A1C range is not age specific. ![]() Some metabolic health experts have more conservative recommendations, setting the maximum normal HbA1c level of 5.0% as the optimal upper limit. People without diabetes who have high HbA1c levels are at increased risk of metabolic disease, heart disease, and dementia. Elevated HbA1c levels have been associated with severe health conditions, such as damage to the eyes, kidneys, heart, nerves, and blood vessels caused by high blood glucose levels. For example, anemia, kidney dysfunction, and high cholesterol can raise your HbA1c levels, while pregnancy, an enlarged spleen, and high vitamin E can lower them. HbA1c Test results can be affected by various factors, which can lead to higher or lower HbA1c levels. An HbA1c level of 6.5% or higher is considered indicative of diabetes. An HbA1c level between 5.7% and 6.4% suggests prediabetes, which means you are at an increased risk of developing diabetes. A normal HbA1c level is below 5.7%, indicating a low risk of developing diabetes. The interpretation may differ depending on whether the test is being used to diagnose diabetes or to monitor diabetes that has already been diagnosed. Your healthcare provider will use the reference ranges, along with your overall health context, to interpret your HbA1c Test Results. Your HbA1c Test Results are presented as a percentage along with the reference ranges of test results considered normal, prediabetes or diabetes. This is a concerning sign and can lead to serious health problems if not addressed. If your HbA1c percentage is too high, it indicates that your average blood glucose level over the past 3 month has also been high. The HbA1c measurement reflects the percentage of hemoglobin A1 that has glucose attached to it. The higher the level of glucose in the blood, the more glucose can attach to hemoglobin. Diabetes is a serious disease that can damage your body’s organs if left uncontrolled. If your body doesn’t produce enough insulin or your cells have trouble using insulin properly, your blood glucose level can become dangerously high, leading to diabetes. With the help of insulin, glucose is taken up by your body’s cells to be used as energy. Glucose is a type of sugar that your body uses as its primary energy source and comes from the food you eat. ![]() The HbA1c Test measures the amount of glucose that has attached to hemoglobin A1 in your blood. When glucose enters the bloodstream, it binds to hemoglobin A1, forming Hemoglobin A1c (HbA1c). Hemoglobin, a protein that is present in red blood cells, transports oxygen from the lungs to the body’s tissues and returns carbon dioxide from the tissues to the lungs.
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